Thrombosis
Preclinical models for evaluating thrombogenesis and anti-thrombotic therapies
Thrombosis is a central driver of ischemic cardiovascular events and a major focus of therapeutic intervention. CorDynamics offers a range of in vitro and in vivo models to support discovery and lead optimization of anti-thrombotic compounds.
Preclinical Models of Thrombosis
CorDynamics supports thrombosis research across multiple mechanistic pathways and vascular contexts. Our models are designed to investigate platelet function, coagulation, and vessel occlusion using physiologically relevant platforms. Available models include:
- Platelet Aggregation Assays: Conducted in whole blood or platelet-rich plasma (PRP), these in vitro tests evaluate compound effects on platelet function and aggregation dynamics.
- In Vivo Arterial and Venous Thrombosis: Includes carotid and coronary arterial thrombosis models, as well as venous thrombosis paradigms, to evaluate thrombus formation under flow and stasis conditions.
These models are used to:
- Screen anti-platelet and anti-thrombotic compounds
- Study dose-response and mechanism of action
- Generate PK/PD data and correlate with thrombotic endpoints
- Support lead selection and translational risk assessment
Why Choose CorDynamics
CorDynamics has deep expertise in thrombosis research, supporting discovery and lead optimization across platelet function, coagulation, and vascular injury models.
We offer validated protocols for platelet aggregation, arterial and venous thrombosis, and integrate PK/PD analysis with mechanistic endpoints to deliver high-quality data for candidate selection and translational insight.
Enabling smarter anti-thrombotic discovery through mechanistically diverse thrombosis models.
