Heart Failure Models
Translational preclinical studies in HFrEF, HFpEF, and ischemia/reperfusion injury
Heart failure is a leading challenge in cardiovascular medicine, driven by ischemic injury, pressure overload, and metabolic dysfunction. CorDynamics provides validated models for HFrEF, HFpEF, and ischemia/reperfusion to support the development of targeted, translational therapies.
Preclinical Models of Heart Failure
Preclinical models of heart failure allow researchers to replicate the pathophysiology of a failing heart under controlled conditions. These models span multiple etiologies:
- HFrEF induced by MI, chronic ischemia, pressure overload, or pacing
- HFpEF associated with hypertension, metabolic syndrome, and diastolic dysfunction
- Ischemia/Reperfusion (IR) injury, where temporary coronary occlusion is followed by reperfusion, mimicking acute coronary syndromes and evaluating tissue salvage and reperfusion injury
These models are crucial in:
- Characterizing contractile dysfunction, dilation, fibrosis, and neurohormonal activation
- Investigating cardioprotective agents, remodeling therapies, and heart failure progression
- Supporting target validation, dose optimization, and mechanistic exploration in early discovery
- Designing IND-enabling studies and bridging to clinical trials
CorDynamics offers both in vivo and ex vivo IR models across various species, including Langendorff heart and in situ coronary ligation models. Robust pathology support, including histology and infarct sizing, complements traditional endpoints like ejection fraction and pressure-volume analysis.
Why Choose CorDynamics
CorDynamics has deep expertise in heart failure and ischemia/reperfusion models, supporting discovery and translational programs across species and study types.
We offer validated protocols for infarction, pressure overload, pacing-induced failure, and HFpEF. Our lab integrates advanced imaging, telemetry, and pressure-volume systems to deliver high-quality cardiovascular data under GLP or non-GLP conditions.
We are a trusted partner to sponsors seeking reliable data to advance heart failure therapies and decode complex disease mechanisms.
