Pressure-Volume Loops
Gold-standard assessment of cardiac contractility, compliance, and performance
Pressure-volume (PV) loop analysis is the most comprehensive method for evaluating ventricular function in preclinical models. CorDynamics integrates PV loop studies into disease and safety programs to quantify real-time cardiac mechanics under precisely controlled loading conditions.
Preclinical PV Loop Studies
PV loops provide simultaneous measurement of ventricular pressure and volume, capturing beat-to-beat cardiac performance across the full cardiac cycle. CorDynamics offers PV loop acquisition in anesthetized models, with protocols tailored to support discovery-stage exploration or high-resolution translational studies. Key functional insights include:
- Contractility and Inotropy: dP/dt max, preload-recruitable stroke work, end-systolic pressure-volume relationshiop (ESPVR)
- Compliance and Diastolic Function: Tau, dP/dt min, end-diastolic pressure-volume relationship (EDPVR)
- Volume Handling: Stroke volume, ejection fraction, cardiac output
- Load Sensitivity Testing: Preload/afterload manipulations with real-time response tracking
These measurements are commonly integrated into studies of heart failure, IR injury, and safety pharmacology to:
- Characterize mechanical function in models of systolic and diastolic dysfunction
- Assess compound effects on pressure-volume relationships across dose ranges
- Support mechanistic and biomarker studies with high-fidelity cardiac data
- Strengthen translational data packages for regulatory submission
Why Choose CorDynamics
CorDynamics has extensive experience performing PV loop studies across rodent and large animal models. Our team designs and executes custom protocols using state-of-the-art instrumentation to deliver consistent, high-quality datasets.
PV loop data can be combined with echo, telemetry, or electrophysiology for a comprehensive view of cardiac function under pharmacological challenge.
Real-time insight into cardiac mechanics to power translational discovery and safety studies.
