In Vivo Anesthetized Models
High-sensitivity studies for comprehensive cardiovascular evaluation
Anesthetized models are among the most sensitive tools available to characterize a compound’s cardiovascular effects. CorDynamics uses these models to support primary safety assessments, explore backup compounds, and guide dose optimization through robust, real-time hemodynamic and electrophysiological measurements.
Preclinical Studies Using Anesthetized Models
These models provide detailed insight into cardiovascular performance in a highly controlled setting. With real-time access to cardiovascular tissues and pressure systems, CorDynamics can evaluate complex endpoints with exceptional precision. Key parameters assessed include:
- Systemic and pulmonary arterial pressures
- Left ventricular pressure and contractility
- Cardiac output and regional blood flow
- Heart rate, ECG, and electrophysiology
- PK/PD integration across dosing regimens
We support a wide range of species, anesthetics, and administration routes. Studies are adaptable for early discovery or formal GLP protocols aligned with global regulatory expectations.
Why Choose CorDynamics
CorDynamics has decades of experience conducting in vivo anesthetized studies using industry-standard platforms such as Notocord, DSI, and emka. Our surgical suites support multiple species, dose routes, and custom protocols for maximum flexibility.
All studies are executed under rigorous QA oversight, with deep expertise in GLP and OECD-compliant safety pharmacology. Discovery-stage programs also benefit from rapid scheduling, customizable designs, and high-resolution cardiovascular data.
Sensitive and flexible in vivo models to evaluate cardiovascular function under controlled conditions.
