Implantable Telemetry
In vivo models for conscious cardiovascular and respiratory monitoring
Telemetry studies are the gold standard for evaluating cardiovascular effects in conscious, freely moving subjects. CorDynamics offers GLP and non-GLP telemetry platforms designed to assess ECG, hemodynamics, and respiratory parameters under real-time, unrestrained conditions.
Preclinical Models Using Telemetry
Telemetry enables the continuous monitoring of cardiovascular function without the confounding effects of anesthesia or restraint. CorDynamics supports both exploratory and regulatory-grade studies, providing rich datasets for safety assessment and pharmacodynamic evaluation.
Study modes range from rapid-turnaround lead screening to comprehensive GLP protocols tailored to regulatory expectations. Multiple data channels are available to meet diverse project needs:
- ECG and Hemodynamics: High-fidelity acquisition of heart rate, rhythm, arterial pressure, and contractility in conscious animals
- Left Ventricular and Dual Pressure Systems: Simultaneous monitoring of left ventricular, systemic, and pulmonary arterial pressures
- Respiratory Telemetry: Integrated systems for respiratory rate, tidal volume, blood pressure, and ECG
- Electrophysiology Testing: Advanced arrhythmia detection and quasi beat-to-beat QT interval correction
Studies can be conducted in sling-restrained or fully unrestrained animals, with optional video monitoring for behavioral correlation. Telemetry is ideal for:
- Investigating cardiovascular liability in safety pharmacology
- Profiling hemodynamic and electrophysiological effects of candidate compounds
- Supporting IND-enabling submissions with compliant GLP studies
- Exploring dose-dependent CV and respiratory effects across compound classes
Why Choose CorDynamics
CorDynamics has decades of experience executing cardiovascular telemetry studies under both GLP and exploratory conditions. We work closely with sponsors to define endpoints, dosing schedules, and analysis parameters aligned with project objectives.
Our facilities are equipped with multi-channel telemetry platforms, video capture systems, and advanced analysis software for real-time data interpretation in conscious animals.
Providing high-resolution cardiovascular and respiratory data in conscious, freely moving models.
